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Recent Publications

For a full list of publications from our faculty, please visit their individual faculty page.
Jacobs M.R., Olivero J.E., Ok Choi H., Liao C.P., Kashemirov B.A., Katz J.E., Gross M.E., McKenna C.E. (2023). Synthesis and anti-cancer potential of potent peripheral MAOA inhibitors designed to limit blood:brain penetration. Bioorg Med Chem. doi: 10.1016/j.bmc.2023.117425.
Rodriguez GM, DePuy D, Aljehani M, et al. (2023). Trends in Epidemiology of Esophageal Cancer in the US, 1975-2018. JAMA Netw Open. doi:10.1001/jamanetworkopen.2023.29497  
Barker, A.D., Alba M.M., Mallick P., Agus, D.B., & Lee, J.S. (2023). An inflection point in cancer protein biomarkers: what was and what's next. Molecular and Cellular Proteomics. https://doi.org/10.1016/j.mcpro.2023.100569
Strelez, C., Jiang, H. Y., & Mumenthaler, S. M. (2023). Organs-on-chips: A decade of innovation. Trends in Biotechnology, 41(3), 278-280. https://doi.org/10.1016/j.tibtech.2023.01.004
Agus, D. B., Nguyen, A., Alpha Sall, A. A., & Bell, J. (2022). COVID-19 and other adult vaccines can drive global disease prevention. The Lancet. https://doi.org/10.1016/S0140-6736(22)02084-0
Battaglin, F., Jayachandran, P., Strelez, C. et al. Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment. Oncogene 41, 4769–4778 (2022). https://doi.org/10.1038/s41388-022-02479-4
W. Xiao, M. Pahlavanneshan, C.Y. Eun, X. Zhang, C. DeKalb, B. Mahgoub, H. Knaneh-Monem, S. Shah, A. Sohrabi, S.K. Seidlits, R. Hill Matrix stiffness mediates pancreatic cancer chemoresistance through induction of exosome hypersecretion in a cancer associated fibroblasts-tumor organoid biomimetic model Matrix Biol., 14 (2022), Article 100111
Richards KE, Xiao W, Hill R, on behalf of the USC Pancreas Research Team. Cancer-Associated Fibroblasts Confer Gemcitabine Resistance to Pancreatic Cancer Cells through PTEN-Targeting miRNAs in Exosomes. Cancers. 2022; 14(11):2812. https://doi.org/10.3390/cancers14112812
Barker, A. D., & Lee, J. S. (2022). Translating “Big Data” in Oncology for Clinical Benefit: Progress or Paralysis (82nd ed.). Cancer Research. https://doi.org/10.1158/0008-5472.CAN-22-0100
Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2021 Oct 26:S2451-9456(21)00437-2. doi: 10.1016/j.chembiol.2021.10.003. Epub ahead of print. PMID: 34715055.
Armani, AM, Lee, JSH. Evaluating the impact of ideation and actualization of multidisciplinary research. Commun Phys 4, 208 (2021).
Tang Y, Chen L-Y, Zhang A, Liao C-P, Gross ME, Kim ES. In Vivo Non-Thermal, Selective Cancer Treatment With High-Frequency Medium-Intensity Focused Ultrasound. IEEE Access, vol. 9, pp. 122051-122066, 2021
Erbe R, Wang Z, Wu S, Xiu J, Zaidi N, La J, Tuck D, Fillmore N, Giraldo NA, Topper M, Baylin S, Lippman M, Isaacs C, Basho R, Serebriiskii I, Lenz HJ, Astsaturov I, Marshall J, Taverna J, Lee J, Jaffee EM, Roussos Torres ET, Weeraratna A, Easwaran H, Fertig EJ. Evaluating the impact of age on immune checkpoint therapy biomarkers. Cell Rep. 2021 Aug 24;36(8):109599.
Ghate NB, Kim S, Spiller E, Kim S, Shin Y, Rhie SK, Smbatyan G, Lenz HJ, Mumenthaler SM, An W. VprBP directs epigenetic gene silencing through histone H2A phosphorylation in colon cancer. Mol Oncol. 2021 Jul 27.
Rocque B, Barbetta A, Singh P, Goldbeck C, Helou DG, Loh YE, Ung N, Lee J, Akbari O, Emamaullee J. Creation of a Single Cell RNASeq Meta-Atlas to Define Human Liver Immune Homeostasis. Front Immunol. 2021 Jul 16;12:679521.
Emamaullee JA, Aljehani M, Hogen RVT, Zhou K, Lee JSH, Sher LS, Genyk YS. Potential association between public medical insurance, waitlist mortality, and utilization of living donor liver transplantation: An analysis of the Scientific Registry of Transplant Recipients. Clin Transplant. 2021 Jul 8.
Strelez C, Chilakala S, Ghaffarian K, Lau R, Spiller E, Ung N, Hixon D, Yoon AY, Sun RX, Lenz HJ, Katz JE, Mumenthaler SMHuman colorectal cancer-on-chip model to study the microenvironmental influence on early metastatic spread. iScience. 2021 May 2;24(5):102509.
Wang H, Brown PC, Chow ECY, Ewart L, Ferguson SS, Fitzpatrick S, Freedman BS, Guo GL, Hedrich W, Heyward S, Hickman J, Isoherranen N, Li AP, Liu Q, Mumenthaler SM, Polli J, Proctor WR, Ribeiro A, Wang JY, Wange RL, Huang SM. 3D Cell Culture Models: Drug Pharmacokinetics, Safety Assessment, and Regulatory Consideration. Clin Transl Sci. 2021 May 13.
Battaglin F, Chan P, Pan Y, Soni S, Qu M, Spiller ER, Castanon S, Roussos Torres ET, Mumenthaler SM, Kay SA, Lenz HJ. Clocking cancer: the circadian clock as a target in cancer therapy. Oncogene. 2021 May;40(18):3187-3200.
Chiang CT, Lau R, Ghaffarizadeh A, Brovold M, Vyas D, Juárez EF, Atala A, Agus DB, Soker S, Macklin P, Ruderman D, Mumenthaler SMHigh-throughput microscopy reveals the impact of multifactorial environmental perturbations on colorectal cancer cell growth. Gigascience. 2021 Apr 19;10(4):giab026.
Grossman RL, Dry JR, Hanlon SE, Johann DJ, Kolatkar A, Lee JSH, Meyer C, Salvatore L, Wells W, Leiman LBloodPAC Data Commons for Liquid Biopsy Data. Gigascience. 2021 Apr 19;10(4):giab026.
Patsch K, Liu C, Zapotoczny G, Sun Y, Sura H, Ung N, Sun RX, Haliday B, Yu C, Aljehani M, Lee JSH, Kashemirov BA, Agus DB, McKenna CE, Ruderman D. Paradoxical androgen receptor regulation by small molecule enantiomers. Proc Natl Acad Sci U S A. 2021 Mar 23;118(12):e2100918118.
Wang Y, Brodin E, Nishii K, Frieboes HB, Mumenthaler SM, Sparks JL, Macklin P. Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach. Sci Rep. 2021 Jan 18;11(1):1710.
Barbetta A, Aljehani M, Kim M, Tien C, Ahearn A, Schilperoort H, Sher L, Emamaullee JMeta-analysis and meta-regression of outcomes for adult living donor liver transplantation versus deceased donor liver transplantation. Am J Transplant. 2020 Dec 10.
Naik N, Madani A, Esteva A, Keskar NS, Press MF, Ruderman D, Agus DB, Socher R. Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains. Nat Commun. 2020 Nov 16;11(1):5727.
Arai H, Xiao Y, Loupakis F, Kawanishi N, Wang J, Battaglin F, Soni S, Zhang W, Mancao C, Salhia B, Mumenthaler SM, Weisenberger DJ, Liang G, Cremolini C, Falcone A, Millstein J, Lenz HJImmunogenic cell death pathway polymorphisms for predicting oxaliplatin efficacy in metastatic colorectal cancer. J Immunother Cancer. 2020 Nov;8(2):e001714.
La J, Cheng D, Brophy MT, Do NV, Lee JSH, Tuck D, Fillmore NR. Real-World Outcomes for Patients Treated With Immune Checkpoint Inhibitors in the Veterans Affairs System. JCO Clin Cancer Inform. 2020 Oct;4:918-928.
Trac N, Chen LY, Zhang A, Liao CP, Poon C, Wang J, Ando Y, Joo J, Garri C, Shen K, Kani K, Gross ME, Chung EJ. CCR2-targeted micelles for anti-cancer peptide delivery and immune stimulation. J Control Release. 2020 Oct 1:S0168-3659(20)30570-8.
Godsey JH, Silvestro A, Barrett JC, Bramlett K, Chudova D, Deras I, Dickey J, Hicks J, Johann DJ, Leary R, Lee JSH, McMullen J, McShane L, Nakamura K, Richardson AO, Ryder M, Simmons J, Tanzella K, Yee L, Leiman LC. Generic Protocols for the Analytical Validation of Next-Generation Sequencing-Based ctDNA Assays: A Joint Consensus Recommendation of the BloodPAC's Analytical Variables Working Group. Clin Chem. 2020 Sep 1;66(9):1156-1166.
Kim S, Choung S, Sun RX, Ung N, Hashemi N, Fong EJ, Lau R, Spiller E, Gasho J, Foo J, Mumenthaler SM. Comparison of Cell and Organoid-Level Analysis of Patient-Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response. SLAS Discov. 2020 Aug;25(7):744-754.
Hasnain Z, Nilanon T, Li M, Mejia A, Kolatkar A, Nocera L, Shahabi C, Cozzens Philips FA, Lee JSH, Hanlon SE, Vaidya P, Ueno NT, Yennu S, Newton PK, Kuhn P, Nieva J. Quantified Kinematics to Evaluate Patient Chemotherapy Risks in Clinic. JCO Clin Cancer Inform. 2020 Jun;4:583-601.
Fong EJ, Strelez C, Mumenthaler SM. A Perspective on Expanding Our Understanding of Cancer Treatments by Integrating Approaches from the Biological and Physical Sciences. SLAS Discov. 2020 Aug;25(7):672-683.
Garvey CM, Lau R, Sanchez A, Sun RX, Fong EJ, Doche ME, Chen O, Jusuf A, Lenz HJ, Larson B, Mumenthaler SM. Anti-EGFR Therapy Induces EGF Secretion by Cancer-Associated Fibroblasts to Confer Colorectal Cancer Chemoresistance. Cancers (Basel). 2020 May 28;12(6).
Febbo PG, Martin AM, Scher HI, Barrett JC, Beaver JA, Beresford PJ, Blumenthal GM, Bramlett K, Compton C, Dittamore R, Eberhard DA, Edelstein D, Godsey J, Gruen A, Hanlon SE, Hicks J, Hovelson D, Hullings M, Johann D, Johnson J, Kolatkar A, Kuhn P, Levine R, Martini JF, Miller DP, Moore C, Moy B, Pathak A, Philip R, Reese D, Royalty W, Ryder M, Sakul H, Salvatore LM, Schade A, Silvestro A, Simmons JK, Simons J, Singh Bhan S, Smalley MD, Somiari SB, Talasaz A, Tewari M, Tseng HR, Vinson J, Wells W, Welsh A, Grossman RL, Lee JSH, Leiman LC. Minimum Technical Data Elements for Liquid Biopsy Data Submitted to Public Databases. Clin Pharmacol Ther. 2020 Apr;107(4):730-734.
Gross ME, Agus DB, Dorff TB, Pinski JK, Quinn DI, Castellanos O, Gilmore P, Shih JC. Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Oncotarget. Prostate Cancer Prostatic Dis. 2020 Mar 3:10.1038/s41391-020-0211-9.
Gerdtsson AS, Thiele JA, Shishido SN, Zheng S, Schaffer R, Bethel K, Curley S, Lenz HJ, Hanna DL, Nieva J, Kolatkar A, Ruiz C, Rodriguez-Lee M, Oakley Iii GJ, Lee JSH, Hicks J, Kuhn P. Single cell correlation analysis of liquid and solid biopsies in metastatic colorectal cancer. Oncotarget. 2019 Dec 17;10(66):7016-7030.
Quach C, Song Y, Guo H, Li S, Maazi H, Fung M, Sands N, O'Connell D, Restrepo-Vassalli S, Chai B, Nemecio D, Punj V, Akbari O, Idos GE, Mumenthaler SM, Wu N, Martin SE, Hagiya A, Hicks J, Cui H, Liang C. A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice. Nat Commun. 2019 Dec 12;10(1):5681.